Peltzer Lab

Publications

A. First authors papers

  • 1. Taraborrelli, L*., Peltzer, N*., Montinaro, A., Kupka, S., Rieser, E., Hartwig, T., Sarr, A., Darding, D., Draber, P., Haas, T.L., Akarca, A., Marafioti, T., Pasparakis, M., Bertin, J., Gough, P.J., Bouillet, P., Strasser, A., Leverkus, M., Silke, S., Walczak, H. LUBAC prevents lethal dermatitis by combined inhibition of TNF-, TRAIL- and CD95L-mediated cell death. Nature Communications 9:3910, 2018 .*co-first authors
  • 2. Peltzer, N*., Darding, M*., Montinaro, A., Draber, P., Draberova, H., Kupka, S., Rieser, E., Fisher, A., Hutchinson, C., Taraborrelli, L., Hartwig, t., Lafont, E., Haas, T.L., Shimizu, Y., Böiers, C., Sarr, A., Rickard, J., Alvarez-Diaz, S., Ashworth, M.T., Beal, A., Enver, T., Bertin, J., Kaiser, W., Strasser, A., Silke, J., Bouillet, P., Walczak, H. LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. Nature 557: 112–117, 2018.*co-first authors
  • 3. Peltzer, N*., Rieser, E.*, Taraborrelli, L., Draber, P., Darding, M., Pernaute, B., Shimizu, Y., Daboh, A., Draberova, H., Montinaro, A., Martinez-Barbera, J.P., Silke, J., Rodriguez, T.A. and Walczak, H. HOIP deficiency caused embryonic lethality by aberrant TNFR1- mediated endothelial cell death. Cell Reports 9: 153-165, 2014 .*co-first authors
  • 4. Peltzer, N., Vanli G., Yang, JY., Widmann, C. Role of mTOR, Bad and Survivin in    RasGAP fragment N-mediated cell protection. Plos One 27;8(6):e68123. 2013
  • 5.Khalil, H.*, Peltzer, N*., Walicki, J., Yang, JY., Dubuis, G., Gardiol, N., Held, W., Bigliardi,     P., Marsland, B., Liaudet, L. and Widmann, C. Caspase-3 protects stressed organs against cell death. Molecular and Cellular Biology 32(22):4523-33, 2012 .*co-first authors
  • 6. Peltzer, N., Bigliardi, P., Widmann, C. UV-B induces cytoplasmic survivin expression in mouse epidermis. Journal of Dermatological Science 67(3):196-9, 2012.
  • 7. Peltzer, N., Roques, N., Poinsot, V., Aguilar, OM., Batut, J., Capela, D. Auxotrophy accounts for nodulation defect of most Sinorhizobium meliloti mutants in the branched- chain amino acid biosynthesis pathway. Molecular Plant-Microbe 21(9):1232-41, 2008.

B. Collaborations

  • 8. Liccardi, G.,  Ramos Garcia, L., Tenev, T., Annibaldi, A.,   Legrand, AJ., Robertson, D, Feltham,  F., Anderton,  H., Darding,  M., Peltzer,  N, Dannappel,  M.,     Schünke, H.,Fava, L., Haschka, M.D., Glatter, T, Nesvizhskii, T., Schmidt, A., Harris, P.A.,  Bertin, J., Gough, P., Villunger, A., Silke, J., Pasparakis, M., Bianchi, K. and Meier, P. RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Molecular Cell 73, 11.010, 2019.
  • 9. Giampazolias, E., Zunino, B., Dhayade, S., Bock, F., Cloix, C., Cao, K., Roca, A., Lopez, J., Ichim, G., Proïcs, E., Rubio-Patiño, C., Fort, L., Yatim, N., Woodham, E., Orozco, S., Taraborrelli, L., Peltzer, N., Lecis, D., Machesky, L., Walczak, H., Albert, ML., Milling, S., Oberst, A., Ricci, JE., Ryan, KM., Blyth, K., Tait, SWG. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nat Cell Biol 19(9): 1116-1129, 2017.
  • 10. Shimizu, Y., Peltzer, N., Sevko, A., Lafont, E., Sarr, A., Draberova, H., Walczak, H. The linear ubiquitin chain assembly complex acts as a liver tumour suppressor and  inhibits hepatocyte apoptosis and hepatitis. Hepatology 65(6): 1963-1978, 2017.
  • 11. Zinngrebe, J., Rieser, E., Taraborrelli, L., Peltzer, N., Hartwig, T., Ren, H., Kovács, I.,  Endres, C., Draber, P., Darding, M., Karstedt, S., Lemke, J., Dome, B., Bergmann, M., Ferguson, B., Walczak, H. LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency  and  autoinflammation.  The  Journal  of  Experimental  Medicine .213(12):2671-2689, 2016
  • 12.Rickard, JA., Anderton, H., Etemadi, N., Nachbur, U., Darding, M., Peltzer, N., Lalaoui, N., Lawlor, KE., Vanyai, H., Hall, C., Bankovacki, A., Gangoda, L., Wei-Lynn Wong, W., Corbin, J., Huang, C., Mocarski, ES., Murphy, JM., Alexander, WS., Voss, AK., Vaux, DL., Kaiser, WJ., Walczak, H., Silke, J. TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice. Elife 2;3, 2014

C. Reviews and comments

  • 13. Peltzer, N.*, and Walczak, H*. Cell Death and Inflammation - A Vital but Dangerous Liaison. Trends in immunology (IF: 13) 40, 387-402, 2019 .*co-corresponding authors
  • 14. Peltzer, N., and Walczak, H. Endothelial Cell Killing by TAK1 Inhibition: A Novel     Anti- angiogenic Strategy in Cancer Therapy. Developmental Cell (IF: 9.6) 48(2):127-128, 2019.
  • 15. Peltzer N, Darding M, Walczak H. Holding RIPK1 on the Ubiquitin Leash in TNFR1  Signaling. Trends Cell Biol (IF: 13.5) 26(6):445-61, 2016
  • 16. Zinngrebe, J*., Montinaro, A*., Peltzer, N*. & Walczak, H. Ubiquitin in the immune    system. EMBO Rep (IF: 8.38), 15, 28-45, 2014 .*co-first authors

D. Patent

  • 17. “A method for treating diseases by combined inhibition of TNF superfamily members and/or cell death signalling pathways (such as inflammation and inflammation-associated diseases including auto-immune diseases, neuro-inflammatory diseases, neuro- degenerative diseases, ischaemic diseases, sepsis, and cancer)” UCL Business PLC; Filed: 22/01/18, Inventors: Henning Walczak, Lucia Taraborrelli* and Nieves Peltzer* .*equal contribution
  • 18. “Allosteric regulation of MLKL activity and inhibitors thereof” UCL Business PLC/University of Tübingen. Inventors: Ana Garcia Saez… Henning Walczak* and Nieves Peltzer* (*equal contribution)
Peltzer Lab

Department for Translational Genomics / 
RG location - CECAD Building
Joseph-Stelzmann Strasse 26
50931 Cologne
m.peltzer[@]uni-koeln.de
www.peltzer-lab.cmmc-uni-koeln.de

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University of Cologne University of Cologne University Hospital of Cologne